Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
13 mcg (500 IU)
63%
Calcium (as Calcium Citrate)
630 mg
48%
Top Medical Research Studies
9.5
Calcium fosfomycin effective for UTIs
We explored the potential of calcium fosfomycin, a well-known antibiotic, in treating urinary tract infections (UTIs). Our focus was on how effectively it works when taken orally by healthy women. We dove into the drug’s urine concentration levels after administration, noting that about 18% of the drug is excreted through urine. This low level of excretion relates back to its poor oral absorption and reliance on the kidneys to filter it out.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
Read More
8
We aimed to explore the possible connection between vitamin D levels and urinary tract infections (UTIs) in children. Our study involved measuring various health markers, including vitamin D levels, in 82 children who had experienced their first UTI and compared these results to 64 healthy controls.
The findings revealed that children with UTIs had significantly lower levels of vitamin D compared to their healthy peers. Specifically, those with acute pyelonephritis exhibited even lower vitamin D levels than those with lower UTIs. We also noted that girls tended to have lower vitamin D levels than boys.
Multivariate analysis indicated that a vitamin D level below 20 ng/ml was associated with a higher likelihood of UTIs in children. Therefore, our results suggest that vitamin D deficiency may indeed pose a risk for urinary tract infections in this population.
The findings revealed that children with UTIs had significantly lower levels of vitamin D compared to their healthy peers. Specifically, those with acute pyelonephritis exhibited even lower vitamin D levels than those with lower UTIs. We also noted that girls tended to have lower vitamin D levels than boys.
Multivariate analysis indicated that a vitamin D level below 20 ng/ml was associated with a higher likelihood of UTIs in children. Therefore, our results suggest that vitamin D deficiency may indeed pose a risk for urinary tract infections in this population.
Read More
8
We explored the potential benefits of vitamin D in tackling urinary tract infections (UTIs) caused by the bacterium E. coli. The study involved mice with varying levels of vitamin D, which were infected to imitate UTIs. Additionally, we collected bladder biopsies from postmenopausal women before and after three months of vitamin D supplementation.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Read More
Most Useful Reviews
9
Effective calcium citrate
50 people found this helpful
I chose calcium citrate for its high bioavailability and absorption. It significantly reduces the risk of urinary tract infections as it alkalises urine and helps prevent kidney stones. The chemical purity of calcium citrate is also reassuring compared to calcium carbonate. Moreover, my doctor advised regular calcium supplementation to maintain bone and muscle health, especially since I have periodic issues with my nails. I recommend this product for its multiple benefits.
Read More
7.5
Beneficial for infections
14 people found this helpful
I prefer calcium citrate as it leads to fewer side effects and aids in vitamin absorption. It specifically helps prevent urinary tract infections by alkalising the urine, which can protect against kidney stones and bladder inflammation. Calcium citrate is chemically pure and can effectively deliver calcium to the bones. I take two capsules in the evening as part of my routine for optimal health.
Read More
7.5
Safe calcium option
7 people found this helpful
I regularly use this calcium complex for my parents. While it contains less calcium than other forms, it offers better absorption and has minimal impact on the risk of urinary tract infections. The citrate salt effectively reduces urinary oxalate levels, making it safer for prolonged use. Additionally, it contains vitamin D3, essential for proper calcium absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
- All Researches
9.5
Calcium fosfomycin effective for UTIs
We explored the potential of calcium fosfomycin, a well-known antibiotic, in treating urinary tract infections (UTIs). Our focus was on how effectively it works when taken orally by healthy women. We dove into the drug’s urine concentration levels after administration, noting that about 18% of the drug is excreted through urine. This low level of excretion relates back to its poor oral absorption and reliance on the kidneys to filter it out.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
By conducting a pharmacokinetic/pharmacodynamic analysis, we established thresholds for its effectiveness based on various dosage regimens. For a single dose of 500 mg, 1000 mg, and a schedule of 1000 mg every 8 hours for 3 days, we identified breakpoints of 8, 16, and 32 mg/L, respectively. Notably, our findings indicated that the chances of success for treating UTIs with the 1000 mg every 8 hours regimen are quite high—over 95%—given the susceptibility profile of the bacteria causing these infections.
Overall, our analysis confirms that using calcium fosfomycin in this manner can provide sufficient urine concentrations to effectively combat UTIs in women, supporting its continued use in this area.
Read More
9
Hybrid protein vaccination study results
We explored how combining a hybrid protein with Vitamin D3 and alum might protect against urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC). This study involved immunizing mice with a new protein made from two virulence factors, Ag43 and UpaH, along with these adjuvants.
The results were promising; we found that the addition of alum or both alum and Vitamin D3 significantly boosted immune responses, particularly in IgG levels and other immune markers. Mice that received these combinations showed a marked reduction in bacterial load in the bladder and kidneys compared to those who were not given these treatments.
However, it’s important to note that while Vitamin D3 was included, its specific effects when separated from the other components could not be precisely evaluated in this study. This means while it seems to be beneficial in tandem with alum, we can't confirm how effective it is on its own for UTI prevention. Overall, our findings indicate that the Ag43::UpaH hybrid protein combined with adjuvants like alum and Vitamin D3 could be a promising avenue for UTI vaccine development.
The results were promising; we found that the addition of alum or both alum and Vitamin D3 significantly boosted immune responses, particularly in IgG levels and other immune markers. Mice that received these combinations showed a marked reduction in bacterial load in the bladder and kidneys compared to those who were not given these treatments.
However, it’s important to note that while Vitamin D3 was included, its specific effects when separated from the other components could not be precisely evaluated in this study. This means while it seems to be beneficial in tandem with alum, we can't confirm how effective it is on its own for UTI prevention. Overall, our findings indicate that the Ag43::UpaH hybrid protein combined with adjuvants like alum and Vitamin D3 could be a promising avenue for UTI vaccine development.
Read More
9
Calcium's role in UTI prevention
We investigated how a combination of hyaluronic acid, chondroitin sulfate, and calcium chloride (collectively referred to as HA+CS+CaCl) could help in preventing urinary tract infections (UTIs). This study used a three-dimensional model of human bladder tissue to assess this solution’s effectiveness. Our focus was on how well it could inhibit bacterial growth, form protective films on bladder surfaces, and prevent bacterial adhesion and biofilm formation.
Our results indicated that HA+CS+CaCl showed promising properties in counteracting bacterial invasion. Specifically, the calcium in this combination played a role in this physico-mechanical mode of action. While we understand that isolating the effects of calcium alone is challenging, the overall findings suggest that this medical solution could offer a viable alternative to antibiotics for treating recurrent UTIs.
By reducing bacterial adherence to the bladder epithelium, HA+CS+CaCl might help in better managing and reducing infections. This approach can be particularly appealing, considering the rising concern over antibiotic resistance in treating UTIs.
Our results indicated that HA+CS+CaCl showed promising properties in counteracting bacterial invasion. Specifically, the calcium in this combination played a role in this physico-mechanical mode of action. While we understand that isolating the effects of calcium alone is challenging, the overall findings suggest that this medical solution could offer a viable alternative to antibiotics for treating recurrent UTIs.
By reducing bacterial adherence to the bladder epithelium, HA+CS+CaCl might help in better managing and reducing infections. This approach can be particularly appealing, considering the rising concern over antibiotic resistance in treating UTIs.
Read More
8
We explored the potential benefits of vitamin D in tackling urinary tract infections (UTIs) caused by the bacterium E. coli. The study involved mice with varying levels of vitamin D, which were infected to imitate UTIs. Additionally, we collected bladder biopsies from postmenopausal women before and after three months of vitamin D supplementation.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Read More
8
Cholecalciferol helps prevent UTIs
We explored the potential benefits of cholecalciferol, commonly known as vitamin D3, in preventing recurrent urinary tract infections (UTIs) among patients with benign prostatic hyperplasia (BPH).
In this study, we followed 389 men suffering from moderate to severe BPH symptoms for two years. The patients were divided into two groups: one received tamsulosin, a standard medication to treat BPH, while the other group received both tamsulosin and cholecalciferol.
Our findings revealed that the group treated with cholecalciferol had a significantly lower incidence of UTIs—4.6% compared to 13.5% in the group receiving only tamsulosin. Additionally, the patients who took vitamin D3 experienced a lower level of prostate-specific antigen (PSA) at the end of the treatment, suggesting a potential added benefit.
Overall, cholecalciferol supplementation appears to offer protective effects against recurrent UTIs for BPH patients on tamsulosin, and it does this without introducing any extra adverse effects.
In this study, we followed 389 men suffering from moderate to severe BPH symptoms for two years. The patients were divided into two groups: one received tamsulosin, a standard medication to treat BPH, while the other group received both tamsulosin and cholecalciferol.
Our findings revealed that the group treated with cholecalciferol had a significantly lower incidence of UTIs—4.6% compared to 13.5% in the group receiving only tamsulosin. Additionally, the patients who took vitamin D3 experienced a lower level of prostate-specific antigen (PSA) at the end of the treatment, suggesting a potential added benefit.
Overall, cholecalciferol supplementation appears to offer protective effects against recurrent UTIs for BPH patients on tamsulosin, and it does this without introducing any extra adverse effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective calcium citrate
50 people found this helpful
I chose calcium citrate for its high bioavailability and absorption. It significantly reduces the risk of urinary tract infections as it alkalises urine and helps prevent kidney stones. The chemical purity of calcium citrate is also reassuring compared to calcium carbonate. Moreover, my doctor advised regular calcium supplementation to maintain bone and muscle health, especially since I have periodic issues with my nails. I recommend this product for its multiple benefits.
Read More
7.5
Beneficial for infections
14 people found this helpful
I prefer calcium citrate as it leads to fewer side effects and aids in vitamin absorption. It specifically helps prevent urinary tract infections by alkalising the urine, which can protect against kidney stones and bladder inflammation. Calcium citrate is chemically pure and can effectively deliver calcium to the bones. I take two capsules in the evening as part of my routine for optimal health.
Read More
7.5
Safe calcium option
7 people found this helpful
I regularly use this calcium complex for my parents. While it contains less calcium than other forms, it offers better absorption and has minimal impact on the risk of urinary tract infections. The citrate salt effectively reduces urinary oxalate levels, making it safer for prolonged use. Additionally, it contains vitamin D3, essential for proper calcium absorption.
Read More
Frequently Asked Questions
9
Effective calcium citrate
50 people found this helpful
I chose calcium citrate for its high bioavailability and absorption. It significantly reduces the risk of urinary tract infections as it alkalises urine and helps prevent kidney stones. The chemical purity of calcium citrate is also reassuring compared to calcium carbonate. Moreover, my doctor advised regular calcium supplementation to maintain bone and muscle health, especially since I have periodic issues with my nails. I recommend this product for its multiple benefits.
7.5
Safe calcium option
7 people found this helpful
I regularly use this calcium complex for my parents. While it contains less calcium than other forms, it offers better absorption and has minimal impact on the risk of urinary tract infections. The citrate salt effectively reduces urinary oxalate levels, making it safer for prolonged use. Additionally, it contains vitamin D3, essential for proper calcium absorption.
7.5
Beneficial for infections
14 people found this helpful
I prefer calcium citrate as it leads to fewer side effects and aids in vitamin absorption. It specifically helps prevent urinary tract infections by alkalising the urine, which can protect against kidney stones and bladder inflammation. Calcium citrate is chemically pure and can effectively deliver calcium to the bones. I take two capsules in the evening as part of my routine for optimal health.
7
We explored the use of a dietary supplement called Uronext, which contains D-mannose, cranberry extract, and vitamin D3, in conjunction with the antibiotic ceftriaxone, to prevent catheter-associated urinary tract infections (CAUTIs) in patients undergoing surgery.
In our study, we observed 120 patients with Foley indwelling catheters divided into two groups. One group received Uronext along with ceftriaxone, while the other group received ceftriaxone alone.
The results were promising for the Uronext group, revealing that 66.67% of patients had no bacterial growth from their catheters by the third to seventh day post-operation, compared to just 38.33% in the control group that received only ceftriaxone. This strong reduction in bacterial presence suggests that Uronext, particularly its vitamin D3 component, may play a beneficial role in preventing infections during the critical early postoperative period.
In our study, we observed 120 patients with Foley indwelling catheters divided into two groups. One group received Uronext along with ceftriaxone, while the other group received ceftriaxone alone.
The results were promising for the Uronext group, revealing that 66.67% of patients had no bacterial growth from their catheters by the third to seventh day post-operation, compared to just 38.33% in the control group that received only ceftriaxone. This strong reduction in bacterial presence suggests that Uronext, particularly its vitamin D3 component, may play a beneficial role in preventing infections during the critical early postoperative period.
8
We explored the potential benefits of vitamin D in tackling urinary tract infections (UTIs) caused by the bacterium E. coli. The study involved mice with varying levels of vitamin D, which were infected to imitate UTIs. Additionally, we collected bladder biopsies from postmenopausal women before and after three months of vitamin D supplementation.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
Interestingly, while vitamin D showed no significant effect on tight junction proteins in bladder cells before any infection, it did have a notable positive impact during the infections. Specifically, we observed that vitamin D helped to induce important proteins called occludin and claudin-14 in the bladder's upper surface cells. This is key because these proteins play a critical role in strengthening the bladder's epithelial barrier, thereby potentially limiting bacterial invasion.
Our findings suggest that vitamin D supplementation could be a useful strategy for restoring and maintaining the integrity of the bladder lining during E. coli infections, making it a promising avenue for individuals prone to UTIs. However, it is important to emphasize that more research is needed to fully understand these effects and how they can be harnessed in everyday health practices.
7
We explored the impact of vitamin D3 supplementation on urinary tract infections (UTIs) and antibiotic use among older Australians through the D-Health Trial. This study involved over 21,000 participants aged 60 to 84 years, who were either given a monthly dose of 60,000 IU of vitamin D3 or a placebo for five years in a rigorous, randomized, double-blind format.
Our focus was primarily on the number of antibiotic prescriptions as a way to measure the potential effects of vitamin D3 on infections. While we noticed a small reduction in overall antibiotic prescriptions and repeat prescription episodes among those taking vitamin D3, the results did not show a significant impact specifically on UTIs.
Notably, there was some evidence suggesting that those with low vitamin D levels at the study's start might benefit more from vitamin D3 supplementation. However, since the overall findings didn’t isolate UTIs specifically, it remains unclear exactly how beneficial vitamin D3 is for this type of infection. Ultimately, while vitamin D may offer some advantage in reducing antibiotic use, we find that the evidence for its effectiveness against urinary tract infections specifically is not conclusive.
Our focus was primarily on the number of antibiotic prescriptions as a way to measure the potential effects of vitamin D3 on infections. While we noticed a small reduction in overall antibiotic prescriptions and repeat prescription episodes among those taking vitamin D3, the results did not show a significant impact specifically on UTIs.
Notably, there was some evidence suggesting that those with low vitamin D levels at the study's start might benefit more from vitamin D3 supplementation. However, since the overall findings didn’t isolate UTIs specifically, it remains unclear exactly how beneficial vitamin D3 is for this type of infection. Ultimately, while vitamin D may offer some advantage in reducing antibiotic use, we find that the evidence for its effectiveness against urinary tract infections specifically is not conclusive.
References
- Al-Shukri AS, Maksimova AV, Dub NI, Kostyukov SV, Manchenko AA, et al. [Prevention of the development of catheter-associated urinary system infections in the early postoperative period]. Urologiia. 2023.
- Pham H, Waterhouse M, Baxter C, Duarte Romero B, McLeod DSA, et al. Vitamin D Supplementation and Antibiotic Use in Older Australian Adults: An Analysis of Data From the D-Health Trial. J Infect Dis. 2022;226:949. 10.1093/infdis/jiac279
- Habibi M, Azimi S, Khoobbakht D, Roghanian P, Asadi Karam MR. Immunization with recombinant protein Ag43::UpaH with alum and 1,25(OH)2D3 adjuvants significantly protects Balb/C mice against urinary tract infection caused by uropathogenic Escherichia coli. Int Immunopharmacol. 2021;96:107638. 10.1016/j.intimp.2021.107638
- Mohanty S, Kamolvit W, Hertting O, Brauner A. Vitamin D strengthens the bladder epithelial barrier by inducing tight junction proteins during E. coli urinary tract infection. Cell Tissue Res. 2020;380:669. 10.1007/s00441-019-03162-z
- Safwat AS, Hasanain A, Shahat A, AbdelRazek M, Orabi H, et al. Cholecalciferol for the prophylaxis against recurrent urinary tract infection among patients with benign prostatic hyperplasia: a randomized, comparative study. World J Urol. 2019;37:1347. 10.1007/s00345-018-2536-8
- Kwon YE, Kim H, Oh HJ, Park JT, Han SH, et al. Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants. Medicine (Baltimore). 2015;94:e594. 10.1097/MD.0000000000000594
- Ramos NL, Sekikubo M, Kironde F, Mirembe F, Sääf M, et al. The impact of vitamin D on the innate immune response to uropathogenic Escherichia coli during pregnancy. Clin Microbiol Infect. 2015;21:482.e1. 10.1016/j.cmi.2014.12.010
- Tekin M, Konca C, Celik V, Almis H, Kahramaner Z, et al. The Association between Vitamin D Levels and Urinary Tract Infection in Children. Horm Res Paediatr. 2015;83:198. 10.1159/000370046
- Hertting O, Holm Å, Lüthje P, Brauner H, Dyrdak R, et al. Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. PLoS One. 2010;5:e15580. 10.1371/journal.pone.0015580
- Ferrão AR, Pestana P, Borges L, Palmeira-de-Oliveira R, Palmeira-de-Oliveira A, et al. Electrolyte Concentration in Urine and Urinary Infection-Is There Any Relation?. Biomedicines. 2025;13. 10.3390/biomedicines13020253
- Brambilla L, Frangione V, Meloni M. Non Clinical Model to Assess the Mechanism of Action of a Combined Hyaluronic Acid, Chondroitin Sulfate and Calcium Chloride: HA+CS+CaCl Solution on a 3D Human Reconstructed Bladder Epithelium. Med Devices (Auckl). 2024;17:47. 10.2147/MDER.S433261
- Rodríguez-Gascón A, Alarcia-Lacalle A, Solinís MÁ, Del Pozo-Rodríguez A, Abajo Z, et al. Pharmacokinetic/Pharmacodynamic Analysis of Oral Calcium Fosfomycin: Are Urine Levels Sufficient to Ensure Efficacy for Urinary Tract Infections?. Pharmaceutics. 2023;15. 10.3390/pharmaceutics15041185
